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The National Cardiovascular Research Infrastructure (NCRI) is a partnership between Duke Clinical Research Institute (DCRI) and the American College of Cardiology Foundation (ACCF) to develop a clinical investigator network based on the data collection activities of the National Cardiovascular Data Registry (NCDR®). The NCRI will unify sites with resources for site recruitment, education, data collection, data standards, and guideline development so large, simple clinical research projects can be executed efficiently.